Buy CJC-1295 Without DAC: Research Guide and Ipamorelin Blend

Buy CJC-1295 Without DAC: Research Guide and Ipamorelin Blend

CJC-1295 Without DAC (Modified GRF 1-29) is a synthetic 30-amino acid growth hormone releasing hormone analog that stimulates pituitary GH secretion in a short-acting pulsatile pattern. Its shorter half-life (~30–60 minutes vs. 6–8 days for the DAC-modified version) makes it particularly suitable for research protocols that require mimicking the physiological pulsatility of endogenous GH secretion rather than continuous sustained elevation.

Combined with ipamorelin, CJC-1295 Without DAC represents the most widely used GH secretagogue dual-pathway stack in preclinical research — with GHRHR activation (CJC-1295) and GHS-R1a activation (ipamorelin) producing synergistic GH responses 5–10× above baseline in rodent models.

Mechanism of Action

• GHRHR Agonism: Directly activates growth hormone-releasing hormone receptors on pituitary somatotrophs
• cAMP Cascade: GHRHR activation increases intracellular cAMP and PKA, triggering GH synthesis and pulse release
• Pulsatility Preservation: Short half-life (without DAC) allows GH to return to baseline between doses, mimicking natural secretion rhythms
• GHRH + GHS-R Synergy: CJC-1295 + ipamorelin co-activation produces supra-additive GH release via simultaneous GHRH and ghrelin pathway stimulation

Research Data

• Dose-dependent GH elevation: 1–100 µg/kg produces 2–10× baseline GH in rodents
• Peak GH response 15–30 min post-administration, return to baseline by 2–3 hours
• Combination with ipamorelin: GH response 5–10× greater than either compound alone
• No tachyphylaxis in twice-daily dosing protocols over 4-week periods
• IGF-1 normalization in GH-deficient rodent models with daily dosing

CJC-1295 With vs. Without DAC — Quick Reference

HPLC Verified

CJC-1295 Without DAC 5mg

Purity: 99%+ HPLC

Half-Life: 30–60 min

Format: Lyophilized Powder

$45

Buy Now

HPLC Verified

CJC-1295 With DAC 10mg

Purity: 99%+ HPLC

Half-Life: 6–8 days

Format: Lyophilized Powder

$65

Buy Now

HPLC Verified

Ipamorelin / CJC-1295 Blend 10mg

Purity: 99%+ HPLC

Synergistic: Dual pathway

Format: Lyophilized Powder

$120

Buy Now

Research Disclaimer: This product is sold strictly for in vitro research and laboratory use only. Not for human consumption. Not medical advice.