Tesofensine for Sale: Research Guide and Sourcing Information

Tesofensine is a triple monoamine reuptake inhibitor originally developed by NeuroSearch for the treatment of Parkinson’s and Alzheimer’s disease, which later attracted significant research interest for its effects on metabolic and body weight regulation. It inhibits the reuptake of serotonin, dopamine, and norepinephrine, producing appetite-suppressing effects through central nervous system pathways distinct from GLP-1 receptor agonists.

Unlike injectable peptide compounds, tesofensine is an oral small molecule. This delivery advantage has made it a subject of ongoing research particularly among researchers studying central obesity mechanisms and CNS-mediated appetite regulation. The compound remains in active research and has not received regulatory approval for any indication as of 2026.

Tesofensine Mechanism of Action

• Serotonin reuptake inhibition: Elevates synaptic serotonin, contributing to appetite suppression and mood modulation in research models
• Dopamine reuptake inhibition: Increases dopaminergic tone, associated with reduced reward-driven feeding behavior in animal models
• Norepinephrine reuptake inhibition: Activates the sympathetic nervous system, contributing to increased energy expenditure and thermogenesis

Tesofensine Research Data

A Phase 2 randomized controlled trial (Lancet, 2008) studied tesofensine in 203 obese participants over 24 weeks. Key published findings:

• At 0.5mg/day, participants achieved a mean weight loss of 12.8 kg (approximately 11.3% of body weight)
• At 1.0mg/day, mean weight loss was 14.1 kg over 24 weeks
• All active treatment arms significantly outperformed placebo (1.0 kg loss)
• Favorable changes in waist circumference and fasting lipid profiles were observed

Tesofensine Dosage Reference

Data from published Phase 2 trial. Provided for research reference only — not dosing guidance for human use.

Side Effects from Trial Data

• Dry mouth (most commonly reported)
• Nausea and constipation
• Heart rate increase (dose-dependent, ~7–8 bpm at 1mg)
• Elevated blood pressure at higher doses
• Insomnia and mood changes in some participants

Tesofensine vs. GLP-1 Agonists — Research Comparison

Where to Buy Tesofensine for Research

Researchers sourcing tesofensine should look for suppliers providing documented purity testing and identity verification. Essential supplier criteria:

• HPLC purity documentation (≥99% preferred)
• Mass spectrometry confirmation of compound identity
• Independent third-party laboratory COA
• Clear research-use-only documentation

HPLC Verified

Tesofensine (KLOW) 80mg

Purity: 99%+ HPLC

Format: Lyophilized Powder

Testing: Third-Party COA

$280

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Research Disclaimer: All content on this page is for educational and scientific reference purposes only. Tesofensine is not approved for human use. This product is sold strictly for in vitro research and laboratory use only. Not for human consumption. Not medical advice.