N-Acetyl Selank Amidate: Research Guide and Where to Buy

What Is N-Acetyl Selank Amidate?

N-Acetyl Selank Amidate is a doubly modified form of Selank — a synthetic heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro) originally developed at the Institute of Molecular Genetics of the Russian Academy of Sciences as a functional analog of tuftsin, an endogenous immunomodulatory tetrapeptide. N-acetylation at the N-terminus and C-terminal amidation significantly increase proteolytic resistance compared to unmodified Selank, extending biological half-life and enhancing blood-brain barrier penetration.

Selank and its derivatives have been studied for over 30 years in Russian neuropharmacology, and Selank itself (unmodified) is approved for medical use in Russia for generalized anxiety disorder. The N-Acetyl Amidate modification represents the most stable and potent form of Selank available for research purposes, with documented activity at approximately 2–4× lower doses than parent Selank.

Mechanism of Action

• GABAergic Modulation: Enhances GABA_A receptor sensitivity through allosteric mechanisms, similar in profile to anxiolytic benzodiazepines but without receptor dependence in research models
• BDNF and NGF Upregulation: Documented increases in brain-derived and nerve growth factor expression in hippocampal and prefrontal tissue
• HPA Axis Regulation: Attenuates stress-induced cortisol elevation and normalizes HPA axis hyperreactivity in repeated-stress rodent models
• Serotonergic Effects: Increases 5-HT synthesis and turnover in limbic regions, contributing to anxiolytic and antidepressant profiles
• Enkephalinase Inhibition: Inhibits the enzyme that degrades enkephalins (endogenous opioid peptides), prolonging natural anxiety-buffering effects
• Immune Modulation: Like parent tuftsin, Selank enhances NK cell activity and macrophage function — unique among anxiolytic compounds

Research Data

Anxiety and Stress

• Significant anxiolytic effect in elevated plus maze, open field, and Vogel conflict tests in rodents — comparable to diazepam at appropriate doses without sedation
• Normalized stress-induced elevation of corticosterone without baseline cortisol suppression
• Reduced anxiety scores in Russian Phase 2 clinical trials for generalized anxiety disorder (parent Selank)

Cognitive Enhancement

• Improved spatial working memory in Morris water maze and radial arm maze protocols
• Enhanced memory consolidation following stress-induced memory impairment
• BDNF increases of ~30–50% in hippocampal tissue 24 hours post-administration

Neuroprotection

• Protected dopaminergic neurons against MPTP-induced damage in Parkinson’s cell models
• Reduced neuroinflammation markers (IL-1β, TNF-α) in LPS-challenged rodent brains

HPLC Verified

N-Acetyl Selank Amidate 20mg

Purity: 99%+ HPLC

Format: Lyophilized Powder

Testing: Third-Party COA

$90

Buy Now

HPLC Verified

N-Acetyl Selank Amidate 30mg

Purity: 99%+ HPLC

Format: Lyophilized Powder

Testing: Third-Party COA

$120

Buy Now

Research Disclaimer: This product is sold strictly for in vitro research and laboratory use only. Not for human consumption. Not medical advice.