5-Amino-1MQ Powder 5mg Research Compound
5-Amino-1MQ (5-amino-1-methylquinolinium) is a small molecule inhibitor of NNMT (nicotinamide N-methyltransferase), an enzyme that catalyzes the methylation of nicotinamide using S-adenosyl methionine (SAM) as the methyl donor. NNMT is overexpressed in adipose tissue and various cancer cell lines, and its inhibition has been studied as a strategy to increase intracellular NAD+ levels, enhance one-carbon metabolism, and reduce adipogenesis in preclinical models. This 5mg vial provides research-grade 5-Amino-1MQ at ≥99% purity, HPLC and MS/MS verified per batch.
Research Background
5-Amino-1MQ was identified as a potent NNMT inhibitor in work published by the Bhatt Lab and collaborators, with subsequent preclinical studies demonstrating that NNMT inhibition in diet-induced obese mice reduced body weight, decreased adipose tissue mass, and improved metabolic parameters including insulin sensitivity and plasma lipids. The proposed mechanism involves NNMT inhibition increasing the SAM:SAH ratio and NAD+ precursor availability, activating sirtuin-mediated metabolic programs. Research interest has also extended to NNMT’s role in cancer metabolism and tumor microenvironment modulation, where its overexpression is associated with poor prognosis in multiple cancer types.
Compound Specifications
- Format: Powder
- Purity: ≥99% (HPLC verified)
- Quantity: 5mg per vial
- Storage: −20°C, protected from light
- Target: NNMT inhibitor
- Molecular Weight: 174.2 Da
Certificate of Analysis
All 5-Amino-1MQ vials are third-party tested by independent ISO-certified laboratories. HPLC and MS/MS validation performed per batch. COA available on request.
For research and laboratory use only. Not for human consumption. Not intended to diagnose, treat, cure, or prevent any disease.
