KPV 5mg Research Peptide
KPV is a synthetic tripeptide (Lys-Pro-Val) derived from the C-terminal sequence of alpha-melanocyte-stimulating hormone (α-MSH). It represents the minimal active fragment responsible for α-MSH’s anti-inflammatory activity, retaining potent immunomodulatory effects without the melanocortin receptor-mediated pigmentation or hormonal effects of the full α-MSH molecule. KPV acts primarily through melanocortin receptor-independent pathways, making it a selective research tool for studying innate immune modulation and gastrointestinal inflammation. This 5mg vial provides research-grade KPV at ≥99% purity, HPLC verified per batch.
Research Background
KPV has been studied extensively in inflammatory bowel disease models. Published research demonstrates KPV reduces NF-κB activation in intestinal epithelial cells and macrophages, suppresses pro-inflammatory cytokine production (TNF-α, IL-6, IL-8), and reduces intestinal permeability markers in colitis models. Oral and intracolonic KPV administration in murine colitis models consistently reduces macroscopic and histological inflammation scores. Cell-penetrating properties of KPV — attributed to its small size — facilitate direct intracellular anti-inflammatory action distinct from receptor-mediated mechanisms.
Compound Specifications
- Format: Lyophilized powder
- Purity: ≥99% (HPLC verified)
- Quantity: 5mg per vial
- Storage: −20°C, protected from light
- Sequence: Lys-Pro-Val
- Molecular Weight: 329.4 Da
Certificate of Analysis
All KPV vials are third-party tested by independent ISO-certified laboratories. HPLC validation performed per batch. COA available on request.
For research and laboratory use only. Not for human consumption. Not intended to diagnose, treat, cure, or prevent any disease.
