Tesamorelin is a fully synthetic 44-residue peptide amide and a structural analogue of endogenous human growth hormone-releasing hormone (GHRH 1–44). Identified in early research literature under the developmental code TH9507, it is chemically designated N-(trans-3-hexenoyl)-[Tyr¹]hGRF(1–44)NH₂. Its defining structural feature is an N-terminal trans-3-hexenoyl acylation on the terminal tyrosine residue — the modification that distinguishes tesamorelin as a discrete chemical entity within the broader GHRH-analogue family (CAS 218949-48-5).
In preclinical literature, tesamorelin has been studied for its agonist activity at the growth hormone-releasing hormone receptor (GHRHR) expressed on anterior-pituitary somatotrophs. Research models have examined how this receptor interaction engages the downstream cAMP/PKA signalling cascade and stimulates endogenous, pulsatile growth-hormone (GH) release — a property that has made the compound a useful probe for investigating the hypothalamic-pituitary-somatotropic axis and its native feedback loops. Published work in journals such as The Journal of Clinical Endocrinology & Metabolism has further explored its role in metabolic and adipose-tissue research contexts.
Structurally, tesamorelin carries the molecular formula C₂₂₁H₃₆₆N₇₂O₆₇S and an average molecular weight of approximately 5,135.87 Da. The N-terminal trans-3-hexenoic acid moiety is of particular analytical interest because it confers resistance to enzymatic cleavage by dipeptidyl peptidase-4 (DPP-4), making stability profiling and method development common focal points in research handling the compound.
Core Power Peptides’ tesamorelin is manufactured to a minimum purity of 99%+, verified by HPLC and mass spectrometry, and lyophilised under sterile conditions. Each batch is third-party tested, with a certificate of analysis available on request.
Storage: Store lyophilised tesamorelin at −20°C for long-term preservation. Once reconstituted with bacteriostatic water, store at 2–8°C and use within 28 days, protecting the vial from direct light and repeated freeze-thaw cycles.
This product is intended strictly for in vitro and laboratory research use only. It is not approved for human consumption or therapeutic application, and no medical or clinical claims are made.
