KPV 10mg Research Peptide
KPV (Lys-Pro-Val) is a synthetic tripeptide derived from the C-terminal active fragment of alpha-melanocyte-stimulating hormone (α-MSH), representing the minimal sequence responsible for α-MSH’s anti-inflammatory activity. It acts through melanocortin receptor-independent, NF-κB-suppressing mechanisms to reduce innate immune activation in gastrointestinal, dermal, and systemic inflammatory models. This 10mg vial provides a larger research quantity of KPV at ≥99% purity for extended or multi-model research protocols, HPLC verified per batch.
Research Background
KPV’s primary research application is in intestinal inflammation models. Multiple published studies demonstrate dose-dependent reductions in colitis severity scores, intestinal permeability, and pro-inflammatory cytokine expression following KPV administration in murine IBD models. KPV’s cell-penetrating properties — enabled by its small tripeptide structure — allow direct intracellular access to NF-κB signaling components, a mechanism distinct from surface receptor-mediated anti-inflammatory peptides. Research has also explored KPV in wound healing and dermal inflammation contexts, where similar NF-κB suppression and cytokine reduction effects have been documented.
Compound Specifications
- Format: Lyophilized powder
- Purity: ≥99% (HPLC verified)
- Quantity: 10mg per vial
- Storage: −20°C, protected from light
- Sequence: Lys-Pro-Val
- Molecular Weight: 329.4 Da
Certificate of Analysis
Third-party tested by independent ISO-certified laboratories. HPLC validation performed per batch. COA available on request.
For research and laboratory use only. Not for human consumption. Not intended to diagnose, treat, cure, or prevent any disease.
